915795-41-4

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 218281-29-9 4(S)-fluoromethyl-1-[N-1(R)-phenylethyl]-2-pyrrolidone 

Downstream Products

• 915795-42-5 (3S,4R)-4-fluoromethyl-3-methyl-2-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Tri-, tetra-substituted-3-aminopyrrolidine derivative

A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria, and which are also highly safe are provided. The compound provided is represented by following formula (I): wherein R1 and R2 represent hydrogen atom, or the like; R3 represents an alkyl group containing 1 to 6 carbon atoms, or the like; R4 and R5 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like, with the proviso that R4 and R5 do not simultaneously represent hydrogen atom; or the substituents R4 and R5 together represent (a) a 3- to 6-membered cyclic structure including the carbon atom shared by R4 and R5 to form a spirocyclic structure with the pyrrolidine ring; R6 and R7 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like; R8 represents a halogen-substituted alkyl group containing 1 to 6 carbon atoms, or the like; X1 represents hydrogen atom or a halogen atom; A represents nitrogen atom or a moiety represented by formula (II):

TRI- OR TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES

It is intended to provide quinolone type synthetic antibacterial agents having a potent antibacterial activity against a broad scope of gram-positive and gram-negative bacteria and a high safety and remedies for infections. A compound represented by the following general formula (I), its salt or hydrate thereof: I wherein R1 and R2 represent each hydrogen, etc.; R3 represents C1-6 alkyl, etc.; R4 and R5 independently represent each hydrogen, C1-6 alkyl, etc., provided that R4 and R5 are not hydrogen atoms at the same time, and the above substituents R4 and R5 may be united and form a spiro ring structure structure together with the pyrrolidine ring; R6 and R7 independently represent each hydrogen or C1-6 alkyl; R8 represents a C1-6 haloalkyl group, etc.; X1 represents hydrogen or halogen; and A represents a nitrogen atom or a partial structure represented by the following general formula (II).