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Upstream product

• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 915302-94-2 (3RS)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylic acid 
• 847373-29-9 O-tert-butyl-N,N'-diisopropylurea 
• 915302-91-9 7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]hept-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1059646-58-0 (-)-7-[(S)-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

HYDRATE FOR MEDICAL PURPOSES

The present invention relates to [7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. This hemihydrate is stable and easy to prepare, and has exc

PROCESS FOR PREPARATION OF TETRASUBSTITUTED 5-AZASPIRO[2.4]- HEPTANE DERIVATIVES AND OPTICALLY ACTIVE INTERMEDIATES THEREOF

The invention provides a process for effective preparation of optical isomers of tetrasubstituted 5-azaspiro[2.4]heptane derivatives which are useful as intermediates in the preparation of quinolonecarboxylic acid derivative type antimicrobials; and intermediates thereof. The invention relates to a process for the preparation of compounds (VII) according to the following reaction formula: I II’ II (III) IV V VI VII.

METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND

Disclosed is a method for commercially producing a spiroaminopyrrolidone derivative as an intermediate for a quinolone antibacterial agent. Specifically disclosed is a method for producing a compound represented by the formula (2) below wherein a compound