91592-49-3

Upstream product

• 91684-84-3 Benzoic acid (2S,3R,4R)-4-acetoxy-5-chloro-3-(diethoxy-phosphorylmethyl)-tetrahydro-furan-2-ylmethyl ester 
• 31843-77-3 1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-3-O-(diethoxyphosphonomethyl)-β-D-ribofuranose 
• 65-71-4 2,4-dihydroxy-5-methylpyrimidine 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 31843-74-0 3-deoxy-3-diethoxyphosphinylmethyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 31843-71-7 3-deoxy-3-[(diethoxyphosphoryl)methyl]-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 31843-75-1 5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 1660-94-2 Tetraethyl methylenediphosphonate 
• 31843-73-9 ((3aR,5S,6R)-5-Formyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ylmethyl)-phosphonic acid diethyl ester 
• 91684-83-2 (E)-3-deoxy-3-diethoxyphosphinylmethylene-1,2;5,6-di-O-isopropylidene-α-D-ribo-hexofuranose 

Downstream Products

• 133272-15-8 Benzoic acid (2S,3S,4R,5R)-3-(ethoxy-hydroxy-phosphorylmethyl)-4-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 133272-14-7 1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-β-D-ribofuranosyl)thymine 
• 133272-19-2 1-(5-O-benzoyl-2,3-dideoxy-3-phosphonomethyl-β-D-ribofuranosyl)thymine disodium salt 
• 133272-16-9 1-(5-O-benzoyl-3-deoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine 
• 133272-17-0 1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine 

Relevant academic research and scientific papers

Synthesis of 2',3'-Dideoxy-3'-(phosphonomethyl)nucleosides, Phosphonate Analogs of 2'-Deoxy-3'-nucleotides

1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-(diethoxyphosphorylmethyl)-β-D-ribofuranose (8) is linked (a) to the protected purine bases ABz, GiB and T, respectively, in the presence of potassium nonaflate and (b) to the silylated pyrimidin

HOMONUCLEOSIDE PHOSPHONIC ACIDS-I. A GENERAL SYNTHESIS OF ISOSTERIC PHOSPHONATE ANALOGS OF NUCLEOSIDE 3'-PHOSPHONATES

A general synthetic route to 3'-deoxy-3'-dihydroxyphosphinylmethyl ribonucleosides (3), the isosteric phosphonate analogs of nucleoside 3'-phosphates, is described.This involved alkylation 1,2;5,6-di-O-isopropylidene-α-D-ribo-hexofuranose-3-ulose (7) with