91595-72-1

Basic information

• Product Name: 2-Oxazolamine, 4,5-dihydro-5-[[4-(phenylmethyl)-1-piperidinyl]methyl]-
• CAS NO: 91595-72-1
• Molecular Formula: C16H23N3O
• Molecular Weight: 273.378
• Mol File: 91595-72-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Oxazolamine, 4,5-dihydro-5-[[4-(phenylmethyl)-1-piperidinyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolamine, 4,5-dihydro-5-[[4-(phenylmethyl)-1-piperidinyl]methyl]-(91595-72-1)
• EPA Substance Registry System: 2-Oxazolamine, 4,5-dihydro-5-[[4-(phenylmethyl)-1-piperidinyl]methyl]-(91595-72-1)

Safety Data

• Hazardous Substances Data: 91595-72-1(Hazardous Substances Data)

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 19981-17-0 sodium cyanamide 
• 78484-00-1 4-Benzyl-1-oxiranylmethyl-piperidine 
• 438634-79-8 1-chloro-3-(4-benzylpiperidin-1-yl)propan-2-ol 

Relevant articles and documents

Synthesis and pharmacological evaluation of 5-dialkylaminomethyl-2-amino-2-oxazolines as H1-antagonists

New 5-dialkylaminomethyl-2-amino-2-oxazolines have been synthezised in two steps from the corresponding dialkylamines. They were evaluated in-vitro as H1-antagonists. Compounds 1c, 1d and 1j significantly antagonized histamine-induced contraction of guinea-pig trachea with a rightward shift of the concentration-response curve to histamine. Compound 1f, 5-[(4-benzyl-1-piperidinyl)methyl]-2-amino-2-oxazoline, induced an increase in acetylcholine Emax (the maximal response to acetylcholine 10-3 M) and a shift to the left of the concentration-response curve. The lack of effect of this compound on histamine-induced contraction rules out a non-selective potentiation of the contraction mechanisms. Preliminary structure-activity results were reported partly based on physicochemical results.