91595-85-6Relevant academic research and scientific papers
2-Amino-2-oxazolines, V: Synthesis of some 5-dialkylaminomethyl-2-amino-2-oxazolines and evaluation of their diuretic activity.
Demotes-Mainard,Tranchot,Cambar,Jarry
, p. 193 - 198 (2007/10/02)
A series of 5-dialkylaminomethyl-2-amino-2-oxazolines was prepared and screened for diuretic activity. These compounds were previously examined for their lipophilic behaviour using a reversed-phase HPLC technique. The capacity factors, expressed as log k'w, were correlated with the partition coefficient log P. A QSAR analysis of the diuretic activity in relation with the lipophilicity was attempted for these structurally related compounds.
2-Amino-5-aminomethyl-2-oxazolines, compositions and use
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, (2008/06/13)
This invention relates to new 2-amino-5-aminomethyl-2-oxazolines, the method of preparing them, and their pharmacological properties making possible their application in cardiovascular, psychotropic, antiinflammatory antiallergic, antihistamine, antiH2 therapy. These new products have the general formula: STR1 wherein R1 and R2 independently represent an alkyl radical of C1 to C4, or a carbocyclic alkyl radical having less than 4 rings, or a carbocyclic radical having less than 4 rings; R1 and R2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms, and either 1 or 0 oxygen atoms. This heterocycle can be substituted by R with R being a lower alkyl, allyl, benzyl, pyridyl, phenyl substituted or not by one or more substituents such as halogen, trifluoromethyl, methyl, methoxy, hydroxy.
