915954-53-9Relevant academic research and scientific papers
Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles
Bonezzi, Katiuscia,Taraboletti, Giulia,Borsotti, Patrizia,Bellina, Fabio,Rossi, Renzo,Giavazzi, Raffaella
, p. 7906 - 7910 (2009)
Highly cytotoxic 1,5-diaryl-1H-imidazoles were studied to clarify the relationship between cytotoxicity and activity as vascular disrupting agents (VDA). All the compounds disorganized the tubulin cytoskeleton, affected endothelial cell morphology and cap
Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin
Bellina, Fabio,Cauteruccio, Silvia,Monti, Susanna,Rossi, Renzo
, p. 5757 - 5762 (2008/12/23)
The in vitro antitumor activity of novel combretastatin-like 1,5- and 1,2-diaryl-1H-imidazoles was evaluated against the NCI 60 human tumor cell lines panel. Compounds 2d and 2g proved to be more cytotoxic than CA-4 in tests involving their evaluation ove
