915969-37-8Relevant articles and documents
Synthesis and application of quinazoline-oxazoline-containing (Quinazox) ligands
Fekner, Tomasz,Mueller-Bunz, Helge,Guiry, Patrick J.
, p. 5109 - 5112 (2007/10/03)
(Chemical Equation Presented) A practical synthesis of potentially tridentate P,N,N-ligands containing two stereogenic elements incorporated into the axially chiral Quinazolinap and centrally chiral 2-oxazoline subunits is reported. The application of these novel hybrid ligands in Pd(0)-catalyzed asymmetric allylic alkylation revealed the matched and mismatched diastereomer, dominant stereogenic element, as well as the effect of the oxazoline R substituent on the level of enantioselectivity (ee's up to 81%).