916042-79-0

Upstream product

• 218290-76-7 (S)-2-{[1-(2-Bromo-phenyl)-meth-(Z)-ylidene]-amino}-propionic acid methyl ester 
• 10065-72-2 L-Alanine methyl ester 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1026635-53-9 (S)-2-[(2-Bromo-benzyl)-methyl-amino]-propionic acid methyl ester 
• 503034-64-8 L-N-2-bromobenzyl-N-methyl-Ala-N'-3-(trimethylsilyl)-Gly-OMe 

Relevant academic research and scientific papers

Synthesis of optically active condensed tetrahydropyridines from α-amino esters

Optically active condensed dihydropyridones 6 could be synthesized from α-amino esters 2 or 3 and o-bromobenzyl bromides or heterocyclic analogues 1. These products resemble isoquinoline and β-carboline alkaloid structures and could be stereoselectively t

Application of peptidyl radicals into a new radical cascade leading to unsaturated γ-lactams

Radical cyclization of dipeptides 1a-h proceeds smoothly to give five- and seven-membered rings in good to moderate total yields using Stork's catalytic tin hydride method. A radical is generated on a protecting group and translocated to the peptide moiety. Following a cyclization reaction, the vinyl radical can abstract hydrogen from a benzyl group on an amine, which results in elimination of the protected amine group. Encouraging results have notably been obtained with amino acids other than glycine.