916051-86-0

Upstream product

• 341036-37-1 N-((2-chloro-5-nitrophenyl)carbamothioyl)benzamide 
• 341036-39-3 2-chloro-5-nitrophenylthiourea 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 916051-07-5 1,1-dimethylethyl {4-chloro-3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}carbamate 
• 4113-04-6 quinoline-6-carbaldehyde 
• 916051-85-9 1,1-dimethylethyl (4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)carbamate 

Downstream Products

• 916051-83-7 N₁-(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)glycinamide 

Relevant academic research and scientific papers

THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS

Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.