916058-70-3Relevant academic research and scientific papers
A vaulted biaryl phosphoric acid-catalyzed reduction of α-imino esters: The highly enantioselective preparation of α-amino esters
Li, Guilong,Liang, Yuxue,Antilla, Jon C.
, p. 5830 - 5831 (2008/02/10)
A new method for the chiral phosphoric acid-catalyzed reduction of α-imino esters using Hantzsch ester is described. A series of 11 α-imino esters were evaluated, and it was shown that imino substrates derived from substituted aryl and alkyl keto esters could be reduced to the corresponding α-amino ester in excellent yield and in enantiomeric excesses from 94 to 99%. Catalyst loading was 5 mol % in each case, and the reactions were run with toluene as the solvent. Copyright
Tandem N-alkylation-C-allylation reaction of α-imino esters with organoaluminums and allyltributyltin
Niwa, Yasuki,Shimizu, Makoto
, p. 3720 - 3721 (2007/10/03)
On treatment of various α-imino esters with organoaluminum reagents and allyltributyltin in the presence of benzoyl peroxide, the tandem reaction proceeded to give the N-alkylation-C-allylation products in good yields. The tandem N-alkyation-C-cyanation also proceeded using silyl or aluminum cyanide to give the aminonitrile in good yield. Copyright
