916139-63-4Relevant academic research and scientific papers
Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase
Zhu, Peiqing,Bi, Yi,Xu, Jinyi,Li, Zan,Liu, Jun,Zhang, Luyong,Ye, Wencai,Wu, Xiaoming
, p. 6966 - 6969 (2009)
A series of 23-hydroxybetulinic acid derivatives were prepared and tested in vitro as a new class of inhibitors of glycogen phosphorylase (GP). Within this series of compounds, 12b (IC50 = 3.5 μM) is the most potent GPa inhibitor. The preliminary SAR results of the 23-hydroxybetulinic acid derivatives are discussed.
