916151-00-3Relevant academic research and scientific papers
"click" synthesis of nonsymmetrical bis(1,2,3-triazoles)
Aizpurua, Jesus M.,Azcune, Itxaso,Fratila, Raluca M.,Balentova, Eva,Sagartzazu-Aizpurua, Malaien,Miranda, Jose I.
supporting information; experimental part, p. 1584 - 1587 (2010/06/16)
Chemical Fig. Repretation Unsymmetrically 1,1'-disubstituted 4,4'-bis-1 H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a "double-click" strategy, two complementary approaches were implemented for the preparation of the key 4-ethynyltriazole Intermediates 5: (a) the stepwise Swern oxidatlon/Ohira-Bestman alkynylation of readily available 4-hydroxymethyl-1,2,3-triazoles 8 and (b) the stepwise cycloaddition of TMS-1,4-butadiyne 9. The method is highlighted by Its compatibility with orthogonally protected and functlonallzed saccharide-peptide hybrids and its ability to be extended to the trlsubstituted counterparts 12.
AZOLE COMPOUNDS USED AS TUBERCULOSTATIC AND LEISHMANICIDE AGENTS
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Page/Page column 32-33, (2008/06/13)
This invention refers to new 1, 2, 3-triazole and imidazole compounds included in the families of compounds represented by general formula VIII (see formula VIII) where: X is an atom of "C" or "N"; where X is "N" the radicals do triazole ring are represen
Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1,2,3-triazole derivatives
Costa, Marilia S.,Boechat, Nubia,Rangel, Erica A.,da Silva, Fernando de C.,de Souza, Alessandra M.T.,Rodrigues, Carlos R.,Castro, Helena C.,Junior, Ivan N.,Lourenco, Maria Cristina S.,Wardell, Solange M.S.V.,Ferreira, Vitor F.
, p. 8644 - 8653 (2008/02/08)
The aim of this work was to describe the synthesis, the in vitro anti-Mycobacterium tuberculosis profile, and the structure-activity relationship (SAR) study of new N-substituted-phenyl-1,2,3-triazole-4-carbaldehydes (3a-l). The reactions of aromatic amin
