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Usage

Uses

Used in Pharmaceutical Applications:
1-(2-ethoxy-2-oxoethyl)-1H-1,2,3-triazole-4-carboxylic acid is used as a building block for the synthesis of complex pharmaceutical molecules due to its unique structure and functional groups, which offer opportunities for innovative research and development in the field.
Used in Materials Science:
In the materials science industry, 1-(2-ethoxy-2-oxoethyl)-1H-1,2,3-triazole-4-carboxylic acid is used as a component in the development of new materials, leveraging its stability and solubility properties to create innovative materials with enhanced properties.
Used in Chemical Engineering:
1-(2-ethoxy-2-oxoethyl)-1H-1,2,3-triazole-4-carboxylic acid is used as a key intermediate in chemical engineering processes, where its versatile structure and functional groups can be utilized to create a wide range of products and improve existing processes.

Upstream product

• 637-81-0 ethyl-2-azidoacetate 
• 471-25-0 Propiolic acid 

Relevant academic research and scientific papers

Boronic acid catalysis for mild and selective [3+2] dipolar cycloadditions to unsaturated carboxylic acids

Herein, the concept of boronic acid catalysis (BAC) for the activation of unsaturated carboxylic acids is applied in several classic dipolar [3 + 2] cycloadditions involving azides, nitrile oxides, and nitrones as partners. These cycloadditions can be used to produce pharmaceutically interesting, small heterocyclic products, such as triazoles, isoxazoles, and isoxazolidines. These cycloadducts are formed directly and include a free carboxylic acid functionality that can be employed for fur-ther transformations, thereby avoiding prior masking or functionalization. In all cases, BAC provides faster reactions, under milder conditions, with much improved product yields and regioselectivities. In some instances, such as triazole formation from the reaction of azides with 2-alkynoic acids, catalysis with ort/io- nitrophenylboronic acid circumvents the undesirable product decarboxylation observed when using thermal activation. By using NMR spectroscopic studies, the boronic acid catalyst was shown to provide activation by a LUMO-lowering effect in the unsaturated carboxylic acid, likely via a monoacylated hemiboronic ester intermediate.

On the reactivity of activated alkynes in copper and solvent-free Huisgens reaction

Terminal alkynes substituted by a carbonyl-type electron-withdrawing group have been found to undergo Huisgens cycloaddition with azides at room temperature in a solvent-free manner; without a need of either heating or catalysis. Metallic salts, other tha

Regioselective synthesis of [1,2,3]-triazoles catalyzed by Cu(I) generated in situ from Cu(0) nanosize activated powder and amine hydrochloride salts

A straightforward and efficient method for the regioselective synthesis of functionalized 1,4-disubstituted [1,2,3]-triazoles, from terminal alkynes and azides, has been established utilizing Cu(0) as the source of the catalytic species. The presumed cata

CHINAZOLINE DERIVATIVES AS AURORA KINASE INHIBITORS

Quinazoline derivatives of formula (I) (A chemical formula should be inserted here - please see paper copy enclosed herewith) formula (I) for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in th