91618-40-5

Upstream product

• 75527-84-3 diphenylmethyl 6,6-dibromopenicillanate 
• 75-07-0 acetaldehyde 

Downstream Products

• 1104737-83-8 diphenylmethyl (3S,5R,6R)-6-[1'(R)-hydroxyethyl]penicillanate 
• 109009-86-1 diphenylmethyl (3S,5R,6S)-6-[1'(R)-hydroxyethyl]penicillanate 
• 483340-27-8 6α-bromo-6β-(1-methoxyiminoethyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester 
• 483340-24-5 6α-bromo-6β-(1-hydroxyethyl)-3,3-dimethyl-4,4,7-trioxo-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester 
• 483340-22-3 6β-acetyl-6α-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid benzyhydryl ester 

Relevant academic research and scientific papers

Diastereoselective synthesis of 6-bromo-6-(1-hydroxyethyl)penicillanate by cross-coupling of 6,6-dibromopenicillanate and acetaldehyde pronmoted with grgnard reagents: Role of amine ligands

Grignard reagent-promoted coupling reaction of diphenylmethyl 6,6-dibromopenicillanate lb with acetaldehyde in the presence of N,N,N',N ,N -pentamethyldiethylenetriamine took place in a highly diastereoselective manner to give diphenylmethyl (1′R,3S,5R,6S)-6- bromo-6-(l′-hydroxyethyl)penicillanate 2b effectively, which is a potent intermediate for the synthesis of carbapenem antibiotics.

Synthesis and biological evaluation of 6-bromo-6-substituted penicillanic acid derivatives as beta-lactamase inhibitors.

The synthesis of a selected set of 6-bromopenicillanic acid derivatives with an additional C6 substituent is reported. All these substances were tested as inhibitors of class A and C beta-lactamase enzymes derived from Escherichia coli (TEM-1) and E. cloa