916180-08-0

Upstream product

• 534595-85-2 3-iodo-indole-2-carboxylic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 916180-11-5 3-(1-(toluene-4-sulfonyl)-indol-3-yl)-1-(toluene-4-sulfonyl)-indole-2-carboxylic acid methyl ester 
• 1027787-43-4 3-(5-methoxy-1-(toluene-4-sulfonyl)-indol-3-yl)-1-(toluene-4-sulfonyl)-indole-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS

The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation.

TREATMENT OF PROTEIN FOLDING DISORDERS

In certain embodiments, the invention is directed to a method for treating a protein folding disorder such as Alzheimer's disease, dementia, Parkinson's disease, Huntington's disease and prion-based spongiform encephalopathy. The method comprises the administration to a subject of a compound of the formula (I) wherein A and B are independently a mono- or bicyclic aromatic group or heteroaromatic cyclic group. In preferred embodiments, the compounds are bis-indole compounds.