91619-38-4

Basic information

• Product Name: 3-(1-PYRROLIDINYLSULFONYL)ANILINE
• Synonyms: TIMTEC-BB SBB002602;3-(PYRROLIDINE-1-SULFONYL)-PHENYLAMINE;3-(PYRROLIDIN-1-YLSULFONYL)ANILINE;3-(1-PYRROLIDINYLSULFONYL)ANILINE;3-(1-PYRROLIDINYLSULPHONYL)ANILINE;1-[(3-AMINOPHENYL)SULFONYL]PYRROLIDINE;BUTTPARK 99\57-92;[3-(pyrrolidin-1-ylsulfonyl)phenyl]amine
• CAS NO: 91619-38-4
• Molecular Formula: C₁₀H₁₄N₂O₂S
• Molecular Weight: 226.3
• Product Categories: Amines;blocks;Heterocycles;Sulfonamides
• Mol File: 91619-38-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 155 °C
• Boiling Point: 422 °C at 760 mmHg
• Flash Point: 209 °C
• Appearance: /
• Density: 1.336 g/cm³
• Vapor Pressure: 2.49E-07mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(1-PYRROLIDINYLSULFONYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-PYRROLIDINYLSULFONYL)ANILINE(91619-38-4)
• EPA Substance Registry System: 3-(1-PYRROLIDINYLSULFONYL)ANILINE(91619-38-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 91619-38-4(Hazardous Substances Data)

Usage

General Description

3-(1-Pyrrolidinylsulfonyl)aniline is a chemical compound with the molecular formula C11H15N3O2S. It is a white solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 3-(1-PYRROLIDINYLSULFONYL)ANILINE is also known by its CAS number 109489-83-4 and can be found in the form of a powder or crystals. It is typically handled and stored in a cool, dry and well-ventilated area, away from sources of heat, ignition or direct sunlight. 3-(1-Pyrrolidinylsulfonyl)aniline is primarily used in chemical research and development, and should be handled with proper safety precautions to avoid any potential hazards.

InChI:InChI=1/C10H14N2O2S/c11-9-4-3-5-10(8-9)15(13,14)12-6-1-2-7-12/h3-5,8H,1-2,6-7,11H2

Upstream product

• 91619-30-6 1-(3-nitrophenylsulfonyl)pyrrolidine 
• 121-51-7 3-nitrobenzenesulphonyl chloride 

Downstream Products

• 729578-92-1 2-chloro-N-[3-(pyrrolidinyl-1-sulfonyl)phenyl]acetamide 
• 1443437-95-3 C₂₅H₂₅F₆N₃O₄S 
• 372095-24-4 N-[3-(pyrrolidinylsulfonyl)phenyl]-(2-chloro-5-nitrophenyl)carboxamide 

Relevant articles and documents

BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF

The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled compounds, and prodrugs thereof. The provided compounds may be tumor necrosis factor ("TNF") receptor associated protein 1 ("TRAP1") modulators (e.g., TRAP1 activators). The provided compounds may also rescue the activity in PTEN-induced kinase 1 ("PINK1") loss of function contexts. The provided compounds may also improve mitochondrial health, function, quality, quantity, and/or activity, and/or reduce the production of reactive oxygen species. The provided compounds may also refold or solubilize aggregated or misfolded proteins such as α-synuclein. The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating a disease in a subject in need thereof).

Synthesis and anticandidal activity of azole-containing sulfonamides

Twenty five benzenesulfonamides containing one imidazole or triazole ring, or two imidazole or triazole rings have been synthesized and evaluated as anticandidal agents. The most active compounds were 5c, 6b, 6c, 6e, and 17b, which exhibited MIC values of 4.55-24.39 mM depending on the clinical isolate. Comparing imidazole to triazole derivatives did not show a clear effect on activity. Compounds containing a N-benzyl group also showed no clear evidence on activity given the fact that they have an extra aromatic ring. Secondary sulfonamides, 5l, 5m, and 5n showed activities that were proportional to their lipophilicity. The activities of N-aryl-substituted derivatives 5j, 5k, 5l, 5m, 5n, and 6j were also proportional to their lipophilicity. Halogenation enhanced the activity as a result of improvement of lipophilicity. The presence of two imidazole or triazole rings in the same compound did not show a clear enhancement of activity.