916201-30-4

Basic information

• Product Name: (S)-2-([1,1'-biphenyl]-2-yl)-1-(pyrrolidin-2-yl)ethanone
• Synonyms: (S)-2-([1,1'-biphenyl]-2-yl)-1-(pyrrolidin-2-yl)ethanone
• CAS NO: 916201-30-4
• Molecular Weight: 266.343
• Mol File: 916201-30-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-([1,1'-biphenyl]-2-yl)-1-(pyrrolidin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-([1,1'-biphenyl]-2-yl)-1-(pyrrolidin-2-yl)ethanone(916201-30-4)
• EPA Substance Registry System: (S)-2-([1,1'-biphenyl]-2-yl)-1-(pyrrolidin-2-yl)ethanone(916201-30-4)

Safety Data

• Hazardous Substances Data: 916201-30-4(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 90-41-5 2-phenylaniline 
• 916143-46-9 1-(tert-butoxycarbonyl)-N-[biphenyl-2-yl]-L-prolinamide 

Downstream Products

• 916141-29-2 (S)-1-(3-(1H-benzo[d]imidazol-2-yl)propanoyl)-N-([1,1'-biphenyl]-2-yl)pyrrolidine-2-carboxamide 
• 916141-36-1 N-biphenyl-2-yl-1-[[(1-methyl-1H-benzimidazol-2-yl)-sulfanyl]acetyl]-L-prolinamide 

Relevant articles and documents

A New Class of Amide Ligands Enable Cu-Catalyzed Coupling of Sodium Methanesulfinate with (Hetero)aryl Chlorides

((2S,4R)-4-Hydroxy-N-(2-methylnaphthalen-1-yl)pyrrolidine-2-carboxamide (HMNPC), an amide derived from 4-hydroxy-L-proline and 2-methyl naphthalen-1-amine, is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides with sulfinic acid salts, allowing for first time the metal-catalyzed coupling of (hetero)aryl chlorides and NaSO2Me. A considerable number of (hetero)aryl chlorides worked well, providing the pharmaceutically important (hetero)aryl methylsulfones in good to excellent yields.