91622-60-5Relevant academic research and scientific papers
Transition-metal free C(sp2)-C(sp2) bond formation: Arylation of 4-aminocoumarins using arynes as an aryl source
Sharma, Abhilash,Gogoi, Pranjal
, p. 9014 - 9025 (2019)
A mild, efficient and transition-metal free synthetic strategy has been developed for the α-arylation of 4-aminocoumarins. This synthetic strategy proceeds via C(sp2)-C(sp2) bond formation between 4-aminocoumarins and aryne precursors in a single step by simple treatment with a fluoride source in the absence of a metal-catalyst. Moreover, this methodology affords good yields of 4-amino-3-arylcoumarin derivatives bearing halide functionality.
Synthesis of Coumarins and Quinolones by Intramolecular Aldol Condensation Reactions of Titanium Enediolates
Fuerstner, Alois,Jumbam, Denis N.,Shi, Nongyuan
, p. 326 - 332 (2007/10/02)
Low-valent titanium prepared by the reduction of TiCl3 with zinc dust oxidatively adds to α-ketoamides or α-ketoesters with the formation of the corresponding titanium enediolates.These 1,2-difunctional nucleophiles, which have hardly been used in organic
Synthesis of Indoles and Isoquinolones from Phenylmalonate Heterocycles
Stadlbauer, Wolfgang,Kappe, Thomas
, p. 467 - 476 (2007/10/02)
A new synthesis of the indole system has been achieved by cyclodehydrogenation of amino phenylmalonate heterocycles.Thus, the 4-amino coumarins 1a,b or the 4-amino-2-quinolones 1c-g are converted to the indoles 2 with palladium on charcoal in boiling diph
