91626-88-9

Basic information

• Product Name: 1,3-bis[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]urea
• CAS NO: 91626-88-9
• Molecular Formula: C₁₉H₁₄N₄O₅
• Molecular Weight: 378.3383
• Mol File: 91626-88-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 662.1°C at 760 mmHg
• Flash Point: 354.2°C
• Density: 1.513g/cm³
• Vapor Pressure: 2.12E-17mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: 1,3-bis[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]urea(91626-88-9)
• EPA Substance Registry System: 1,3-bis[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]urea(91626-88-9)

Safety Data

• Hazardous Substances Data: 91626-88-9(Hazardous Substances Data)

Usage

General Description

1,3-bis[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]urea is a chemical compound that belongs to the class of ureas. It is a white solid with the molecular formula C20H18N4O6 and a molar mass of 410.38 g/mol. The compound is used in organic synthesis and pharmaceutical research. It possesses two urea functionalities and two isoindoline-based moieties, making it a versatile building block for the synthesis of complex organic molecules. The chemical structure of 1,3-bis[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]urea makes it a potential candidate for the development of new drugs and materials due to its unique and diverse reactivity.

Upstream product

• 5332-26-3 N-(bromomethyl)phtalimide 
• 46394-37-0 phtalimidomethyl isocyanate 

Relevant articles and documents

Alkylation of Nitrocyanamide. A New Synthesis of Isocyanates

Thirteen alkyl halides (primary, secondary, and tertiary aliphatic including alicyclic, aralkyl, and heteroalkyl systems) and certain non-vicinal dihalides on treatment with silver nitrocyanamide are converted into the corresponding isocyanates (63-95percent).Intermediate alkylnitrocyanamides, spectroscopically detected, thermolysed (-20-80 deg C) to the expected isocyanates.In certain examples silver nitrocyanamide is generated in situ from sodium nitrocyanamide and silver nitrate.Silver nitrocyanamide does not react with cyclopropyl bromide, acetyl chloride, toluene-p-sulphonyl chloride, phenacyl bromide and 2-bromomethyldioxolane (27), and the ethylene acetal (28) of 1-bromo-4-iodopentacyclo-nonan-9-one.Silver nitrocyanamide reacts with 4,6-bis(bromomethyl)-3,7-dimethyl-1,5-diazabicyclo3.3.0)octane-2,8-dione (26), to give an intractable mixture.Vicinal dihalides give erratic results without detectable formation of vicinal di-isocyanates: unisolated 2-bromoethyl isocyanate (tentative assignment) has been detected in a product mixture from ethylene dibromide; an expected rearrangement during the reaction with 1,2-dibromocyclobutane, brought about the formation of 4-bromobut-3-enyl isocyanate isolated as ethyl 4-bromobut-3-enylcarbamate in low yield; and 1,2-dibromocyclohexane gives 2-bromocyclohexyl isocyanate isolated as ethyl N-(2-bromocyclohexyl)-carbamate in low yield.