916323-63-2Relevant academic research and scientific papers
A second-generation total synthesis of spirastrellolide A methyl ester
Paterson, Ian,Maltas, Philip,Dalby, Stephen M.,Lim, Jong Ho,Anderson, Edward A.
supporting information; experimental part, p. 2749 - 2753 (2012/04/17)
Marine macrolides: An improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the crucial macrolactonization step on the substitution pattern of the C22-C24 linker region. Copyright
Total synthesis of spirastrellolide A methyl ester - Part 1: Synthesis of an advanced C17-C40 bis-spiroacetal subunit
Paterson, Ian,Anderson, Edward A.,Dalby, Stephen M.,Lim, Jong Ho,Genovino, Julien,Maltas, Philip,Moessner, Christian
, p. 3016 - 3020 (2008/12/23)
Out of the blue: The marine macrolide spirastrellolide A is a potent and selective inhibitor of protein phosphatase 2A and a lead for anticancer therapies. A flexible and modular synthetic strategy has been developed with two routes for the construction o
