91638-67-4Relevant academic research and scientific papers
Synthesis of secasterol and 24-episecasterol and their toxicity for MCF-7 cells
Khripach,Zhabinskii,Gulyakevich,Konstantinova,Misharin, A. Yu.,Mekhtiev,Timofeev,Tkachev, Ya. V.
, p. 746 - 754 (2010)
The convergent synthesis of biosynthetic precursors of brassinosteroids with a Δ2-bond in cycle A-secasterol and 24-episecasterol-was performed. The key stages in the construction of the side chain in these compounds were the Julia olefination of the steroid 22-aldehyde followed by the Sharpless asymmetric dihydroxylation of the intermediate Δ22- olefin. The cytotoxicity of the synthesized compounds for breast carcinoma MCF-7 cells was assessed.
Stereoselective carbon-carbon bond formation via 1,2-asymmetric induction by a β-substituent in the reaction of α-chloro sulfides with organozinc reagents
Raghavan,Raju Chowhan
, p. 327 - 339 (2019/05/21)
The stereoselectivity of C-C bond formation in the reaction of o-chlorosulfides with a variety of organozinc reagents has been investigated. The study reveals excellent 1,2-asymmetric induction by a β-siloxy substituent and moderate 1,2-induction by the β
SYNTHESIS OF BRASSINOLIDE AND ITS ANALOGS
Khripach, V. A.,Zhabinskii, V. N.,Ol'khovik, V. K.,Lakhvich, F. A.
, p. 1699 - 1706 (2007/10/02)
A new version of the synthesis of brassinosteroids of the 28C series is described.It is based on stigmasterol and uses the reaction of steroidal 22-aldehydes with aryl sulfones.
