916440-85-2Relevant academic research and scientific papers
Isatin derivatives with activity against apoptosis-resistant cancer cells
Evdokimov, Nikolai M.,Magedov, Igor V.,McBrayer, Dominic,Kornienko, Alexander
, p. 1558 - 1560 (2016/07/27)
In a search of small molecules active against apoptosis-resistant cancer cells, a series of isatin-based heterocyclic compounds were synthesized and found to inhibit proliferation of cancer cell lines resistant to apoptosis. The synthesis of these compounds involved a condensation of commercially available, active methylene heterocycles with isatin proceeding in moderate to excellent yields. The heterocyclic scaffolds prepared in the current investigation appear to be a useful starting point for the development of agents to fight cancers with apoptosis resistance, and thus, associated with dismal prognoses.
7-SUBSTITUTED INDIRUBIN-3'OXIMES AND THEIR APPLICATIONS
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Page/Page column 5, (2011/01/05)
The invention relates to new 3′-, 7-substituted-indirubins of formula (I) wherein R represents N—OH, N—O-alkyl or N—O—CO-alkyl, NO—(Ra)n1-Het, N—O—(Y)n1—NRaRb, N—O—CO—N(RbRc), ra
