916441-12-8Relevant academic research and scientific papers
A fast and large-scale synthesis of 3-formyl-2-mercaptoquinolines
Nandeshwarappa, Belalakatte,Aruna Kumar, Doyijode,Bhojya Naik, Halehatty,Mahadevan, Kittappa
, p. 1997 - 2003 (2006)
A convenient, efficient, and inexpensive procedure for the synthesis of 3-formyl-2-mercaptoquinolines 2a-l has been developed by a simple one-pot reaction of 3-formyl-2-chloroquinolines 1a-l with sodium sulfide and hydrochloric acid in ethanol. The structures of all the synthesized compounds were elucidated on the basis of elemental analyses and IR, 1 H NMR, and mass spectral data. Copyright Taylor & Francis Group, LLC.
One-pot three-component synthesis of 2H-thiopyrano[2,3-b]quinoline-2,3-dicarboxylates from 2-mercaptoquinoline-3-carbaldehydes, dialkyl acetylenedicarboxylates and Ph3P
Alizadeh, Abdolali,Roosta, Atefeh,Amir Ashjaee Asalemi, Kaveh
, p. 435 - 442 (2018/03/21)
An extremely concise one-pot procedure toward the synthesis of 2H-Thiopyrano [2,3-b]quinoline-2,3-dicarboxylates whose applications as medicines is predictable has been established. This approach produces three fused rings evolving from the formation of four new carbon–carbon bonds and a stereogenic center in a one-pot protocol.
An efficient carbodiimide-mediated synthesis and dna-binding studies of novel 2-chloro/mercapto-quinoline-fused 1,3-thiazolidinones via one-pot three-component condensation
Lamani, Devappa S.,Reddy, K.R. Venugopala,Naik, H.S. Bhojya,Naik, H.R. Prakash,Naik
scheme or table, p. 49 - 59 (2010/10/04)
A new and efficient method for the preparation of 2-(2-chloroquinolin-3-yl)-3-(4-methylphenyl)-1, 3-thiazolidin-4-one derivatives has been assembled by DCC:-mediated three-component one-pot reaction of amine, aldehyde, and mercaptoacetic acid. The final compounds were obtained in quantitative yields within 50 min. The synthesized compounds were characterized by elemental analysis, FT-IR, 1H-NMR, and mass spectral data. The selected compounds were studied for interaction with calf thymus DNA by electronic spectra, viscosity measurements as well as thermal denaturation studies. On binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. The binding constant (Kb) had a value of 5.3 × 105 M-1 for 2a and 5.8 × 105 M-1 for 3a. The viscosity measurements indicated that the viscosity of sonicated rod-like DNA fragments increased.
