916449-23-5Relevant academic research and scientific papers
Discovery and SAR of hydantoin TACE inhibitors
Yu, Wensheng,Guo, Zhuyan,Orth, Peter,Madison, Vincent,Chen, Lei,Dai, Chaoyang,Feltz, Robert J.,Girijavallabhan, Vinay M.,Kim, Seong Heon,Kozlowski, Joseph A.,Lavey, Brian J.,Li, Dansu,Lundell, Daniel,Niu, Xiaoda,Piwinski, John J.,Popovici-Muller, Janeta,Rizvi, Razia,Rosner, Kristin E.,Shankar, Bandarpalle B.,Shih, Neng-Yang,Arshad Siddiqui,Sun, Jing,Tong, Ling,Umland, Shelby,Wong, Michael K.C.,Yang, De-yi,Zhou, Guowei
scheme or table, p. 1877 - 1880 (2010/07/04)
We disclose inhibitors of TNF-α converting enzyme (TACE) designed around a hydantoin zinc binding moiety. Crystal structures of inhibitors bound to TACE revealed monodentate coordination of the hydantoin to the zinc. SAR, X-ray, and modeling designs are d
