916454-57-4

Basic information

• Product Name: 2-Thiophenecarbonitrile, 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
• Synonyms: 2,2'-(5-CYANOTHIOPHENE-2,4-DIYL)BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)
• CAS NO: 916454-57-4
• Molecular Formula: C17H25B2NO4S
• Molecular Weight: 361.078
• Mol File: 916454-57-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarbonitrile, 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarbonitrile, 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-(916454-57-4)
• EPA Substance Registry System: 2-Thiophenecarbonitrile, 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-(916454-57-4)

Safety Data

• Hazardous Substances Data: 916454-57-4(Hazardous Substances Data)

Upstream product

• 1003-31-2 thiophene-2-carbonitrile 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Downstream Products

• 942070-34-0 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-thiophene-2-carbonitrile 

Relevant articles and documents

Harnessing C-H Borylation/Deborylation for Selective Deuteration, Synthesis of Boronate Esters, and Late Stage Functionalization

Ir-catalyzed deborylation can be used to selectively deuterate aromatic and heteroaromatic substrates. Combined with the selectivities of Ir-catalyzed C-H borylations, uniquely labeled compounds can be prepared. In addition, diborylation/deborylation reactions provide monoborylated regioisomers that complement those prepared by C-H borylation. Comparisons between Ir-catalyzed deborylations and Pd-catalyzed deborylations of diborylated indoles described by Movassaghi are made. The Ir-catalyzed process is more effective for deborylating aromatics and is generally more effective in the monodeborylation of diborylated thiophenes. These processes can be applied to complex molecules such as clopidogrel.