916483-53-9

Upstream product

• 1013-88-3 Benzophenone imine 
• 916483-52-8 2-(4-bromo-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide 
• 804550-60-5 2-bromo-N-(2,3-difluorophenyl)acetamide 
• 916483-51-7 2-chloro-N-(2,3-difluorophenyl)acetamide 
• 4519-40-8 2,3-difluoroanilline 

Downstream Products

• 786681-68-3 2-(4-amino-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide 
• 916483-55-1 tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate hydrochloride 
• 916483-48-2 N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-methoxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide hydrochloride 
• 916483-47-1 tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate 
• 916483-50-6 N-(2,3-difluorophenyl)-2-{4-[(7-ethoxy-5-hydroxyquinazolin-4-yl)amino]-1H-pyrazol-1-yl}acetamide 

Relevant academic research and scientific papers

QUINAZOLINE DERIVATIVES

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also

Two new syntheses of a 4-aminopyrazole: Condensation of an N-substituted vinamidinium salt with a functionalized hydrazine

Two novel syntheses of a key 4-aminopyrazole synthetic building block are described. Both routes avoid the potentially explosive precursors that were used in the previously patented route. A salt of a vinamidinium cation previously used in 5-aminopyrimidi

QUINAZOLINES AND THEIR USE AS AURORA KINASE INHIBITORS

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also