916483-57-3

Upstream product

• 2713-34-0 3,5-difluorophenol 
• 144891-25-8 3,5-difluorophenyl ethyl ether 
• 916483-56-2 4-ethoxy-2,6-difluorobenzoic acid 
• 1373920-79-6 2,6-difluoro-4-ethoxybenzoyl chloride 

Downstream Products

• 916483-58-4 4-ethoxy-2,6-difluorobenzonitrile 
• 916483-61-9 5-{[(2R)-1-benzylpyrrolidin-2-yl]methoxy}-7-ethoxyquinazolin-4(3H)-one 
• 916483-55-1 tert-butyl (2R)-2-[({4-[(1-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)amino]-7-ethoxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate hydrochloride 

Relevant academic research and scientific papers

QUINAZOLINE DERIVATIVES

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also

Novel synthesis of differentially substituted 5,7-dialkoxyquinazolin-4-ones

The preparation of 7-ethoxy-5-fluoroquinazolin-4-one, starting from 3,5-difluorophenol, is described. Further reaction with alkoxide then gives differentially substituted 5,7-dialkoxyquinazolin-4-ones. Copyright Taylor & Francis Group, LLC.

QUINAZOLINES AND THEIR USE AS AURORA KINASE INHIBITORS

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also