916484-38-3Relevant academic research and scientific papers
Synthesis and stability of a homologous series of triynol natural products and their analogues
Luu, Thanh,Tykwinski, Rik R.
, p. 8982 - 8985 (2007/10/03)
A series of polyyne natural products 1, 13, and 31 and analogues 14, 21, and 22 are synthesized in six steps. The key step is a Fritsch-Buttenberg- Wiechell rearrangement in which a triyne framework is formed from the appropriate dibromoolefin precursor.
The first synthesis of the epoxide-containing macrolactone nucleus of oximidine I
Harvey, Joanne E.,Raw, Steven A.,Taylor, Richard J. K.
, p. 7209 - 7212 (2007/10/03)
A synthesis of the epoxydiene-containing macrolide nucleus of oximidine I is reported, starting from commercially available 3-butyn-1-ol. The key macrocyclisation step is achieved using Horner-Wadsworth-Emmons methodology in the presence of an epoxide.
