916489-73-1Relevant academic research and scientific papers
Orally bioavailable potent soluble epoxide hydrolase inhibitors
Sung, Hee Hwang,Tsai, Hsing-Ju,Liu, Jun-Yan,Morisseau, Christophe,Hammock, Bruce D.
, p. 3825 - 3840 (2008/02/13)
A series of N,N′-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane α to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activi
Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors
Hwang, Sung Hee,Morisseau, Christophe,Do, Zung,Hammock, Bruce D.
, p. 5773 - 5777 (2007/10/03)
A 192-member library of N,N′-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phen
IMPROVED INHIBITORS FOR THE SOLUBLE EPOXIDE HYDROLASE
-
Page/Page column 71, (2010/11/08)
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases
