916501-75-2

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 163457-34-9 (+)-(4S)-3-<(2'R)-2'-((benzyloxy)methyl)butanoyl>-4-benzyl-2-oxazolidinone 
• 219610-75-0 (S)-2-((benzyloxy)methyl)butan-1-ol 

Downstream Products

• 916501-76-3 (S)-(2-ethylhex-3-enyloxymethyl)benzene 
• 1643478-37-8 (2R,3R,4R,6R,7S)-7,9-bis(tert-butyldimethylsilyloxy)-2-ethyl-3-(4-methoxybenzyloxy)-4,6-dimethylnonan-1-ol 
• 1312543-56-8 C₃₈H₅₈O₄Si 
• 1643478-35-6 (5S)-5-((2R,4R)-4-((4R,5R)-5-ethyl-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)pentan-2-yl)-2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecane 
• 1312543-54-6 (3R,4R,5R,7R,8S,11E,13E)-8-(tert-butyldimethylsilyloxy)-3-ethyl-5,7-dimethyl-10-oxo-14-phenyltetradeca-1,11,13-trien-4-yl acrylate 
• 1312543-53-5 C₂₅H₃₂O₄ 
• 1312543-55-7 (1E,3E,7S,8R,10R,11R,12R)-7-(tert-butyldimethylsilyloxy)-12-ethyl-11-hydroxy-8,10-dimethyl-1-phenyltetradeca-1,3,13-trien-5-one 
• 1312543-71-7 C₃₁H₄₆O₄Si 
• 1643478-70-9 (5R,6R)-6-((2R,4R,5S,8E,10E)-11-(2-chloro-3-hydroxyphenyl)-5-hydroxy-4-methyl-7-oxoundeca-8,10-dien-2-yl)-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 1643478-68-5 (5R,6R)-6-((2R,4R,5S,8E,10E)-5-(tert-butyldimethylsilyloxy)-11-(3-(tert-butyldimethylsilyloxy)-2-chlorophenyl)-4-methyl-7-oxoundeca-8,10-dien-2-yl)-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 1643478-66-3 (3R,4R,5R,7R,8S,11E,13E)-8-(tert-butyldimethylsilyloxy)-14-(3-(tert-butyldimethylsilyloxy)-2-chlorophenyl)-3-ethyl-5,7-dimethyl-10-oxotetradeca-1,11,13-trien-4-yl acrylate 
• 1643478-31-2 (2R,3S,4R,5S)-5,7-bis(tert-butyldimethylsilyloxy)-2-((4S,5R)-5-ethyl-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylheptan-3-ol 
• 1643478-29-8 (3R,4S,5S,6S,7R,8S)-8,10-bis(tert-butyldimethylsilyloxy)-3-((4-methoxybenzyloxy)methyl)-5,7-dimethyldecane-4,6-diol 
• 1643478-64-1 (1E,3E,7S,8R,10R,11R,12R)-7-(tert-butyldimethylsilyloxy)-1-(3-(tert-butyldimethylsilyloxy)-2-chlorophenyl)-12-ethyl-11-hydroxy-8,10-dimethyltetradeca-1,3,13-trien-5-one 

Relevant academic research and scientific papers

A concise approach for the synthesis of bitungolides: Total syntheses of (-)-bitungolide B & e

The first total synthesis of (-)-bitungolide B and a second-generation total synthesis of (-)-bitungolide E are described. The cornerstone of the approach comprises a convergent and flexible route involving Brown crotylation, highly diastereoselective sub

Synthesis of plakortone B and analogs

Use of a palladium-mediated alkoxycarbonylation/lactonization process provides a variable route to analogs of the plakortones. Four different analogs, including natural plakortone B, have been synthesized via this route.

Synthetic studies of microtubule stabilizing agent peloruside A: An asymmetric synthesis of C10-C24 segment

An asymmetric synthesis of the C10-C24 fragment of the potent antitumor macrolide, peloruside A is described. All three stereogenic centers have been enantioselectively constructed utilizing Evans alkylation, Brown asymmetric allylboration, and a substrate controlled epoxide formation. Other key reactions involved Grubbs's ring-closing olefin metathesis and Ando's Z-selective olefination reaction.