916510-26-4

Basic information

• Product Name: (2-amino-4-chlorophenyl)cyclohexylmethanone
• Synonyms: (2-amino-4-chlorophenyl)cyclohexylmethanone
• CAS NO: 916510-26-4
• Molecular Weight: 237.729
• Mol File: 916510-26-4.mol

Chemical Properties

• CAS DataBase Reference: (2-amino-4-chlorophenyl)cyclohexylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-4-chlorophenyl)cyclohexylmethanone(916510-26-4)
• EPA Substance Registry System: (2-amino-4-chlorophenyl)cyclohexylmethanone(916510-26-4)

Safety Data

• Hazardous Substances Data: 916510-26-4(Hazardous Substances Data)

Upstream product

• 38487-86-4 2-amino-4-chlorobenzonitrile 
• 931-50-0 cyclohexylmagnesium bromide 

Relevant articles and documents

Discovery of novel PTHR1 antagonists: Design, synthesis, and structure activity relationships

The discovery and optimization of a novel series of PTHR1 antagonists are described. Starting from known PTHR1 antagonists, we identified more potent 1,4-benzodiazepin-2-one derivatives by means of a scaffold-hopping approach. The representative compound 23 (DS08210767) exhibited nanomolar-level PTHR1 antagonist activity and potential oral bioavailability in a pharmacokinetic study.

BENZOTRIAZEPINONE DERIVATIVES

The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-1 or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

BENZOTRIAZEPINONE DERIVATIVES

The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.