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916516-91-1

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916516-91-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 916516-91-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,6,5,1 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 916516-91:
(8*9)+(7*1)+(6*6)+(5*5)+(4*1)+(3*6)+(2*9)+(1*1)=181
181 % 10 = 1
So 916516-91-1 is a valid CAS Registry Number.

916516-91-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-bromo-2-chloro-1-(2-iodoethyl)benzene

1.2 Other means of identification

Product number -
Other names 4-Bromo-2-chloro-1-(2-iodoethyl)-benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:916516-91-1 SDS

916516-91-1Downstream Products

916516-91-1Relevant articles and documents

Removal of sphingosine 1-phosphate receptor-3 (S1P3) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P1 agonists with reduced effect on heart rate

Hamada, Maiko,Nakamura, Mitsuharu,Kiuchi, Masatoshi,Marukawa, Kaoru,Tomatsu, Ayumi,Shimano, Kyoko,Sato, Noriko,Sugahara, Kunio,Asayama, Mahoko,Takagi, Kan,Adachi, Kunitomo

experimental part, p. 3154 - 3168 (2010/10/03)

A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate receptor-1 (S1P1) receptor agonists with potent immunomodulatory activity accompanied by little or no effect on heart rate. Many of the synthesized compounds sufficiently decreased the number of peripheral blood lymphocytes. Some of the phosphates had potent agonism at S1P1 but no agonism at S1P3, which had been reported to be a receptor responsible for heart rate reduction. Although high S1P1/S1P 3 selectivity was considered to be favorable to reduce the effect on heart rate, almost all the phosphates showed a remarkable heart rate lowering effect in vivo. The results suggest that other factors in addition to S1P 3 agonism should be responsible for the heart rate reduction caused by S1P1 agonists. Only 2-amino-2-[2-[2′-fluoro-4′-(4- methylphenylthio)biphenyl-4-yl]ethyl]propane-1,3-diol (6d) was identified as a desired S1P1 receptor agonist having both the immunomodulatory activity and an attenuated effect on heart rate by a unique screening flow using in vivo evaluating systems primarily.

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