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Usage

Uses

Used in Pharmaceutical Industry:
3-[(Z)-Butylidene]-5-hydroxyisobenzofuran-1(3H)-one is used as a potential pharmaceutical candidate due to its unique structural and chemical properties. Its presence of a butylidene group and hydroxyl group may offer opportunities for the development of new drugs with novel mechanisms of action.
Used in Chemical Industry:
In the chemical industry, 3-[(Z)-Butylidene]-5-hydroxyisobenzofuran-1(3H)-one can be utilized as a building block or intermediate in the synthesis of various organic compounds. Its specific structural features may enable the creation of new chemical entities with diverse applications.
Used in Drug Discovery and Development:
3-[(Z)-Butylidene]-5-hydroxyisobenzofuran-1(3H)-one is used as a starting material in drug discovery and development processes. Its potential biological activities and unique chemical structure make it a valuable compound for exploring new therapeutic agents and advancing the field of medicinal chemistry.

Upstream product

• 148345-03-3 (Z)-5-methoxy-3-(1-butylidene)phthalide 
• 109-72-8 n-butyllithium 
• 27550-59-0 4-hydroxyphthalic anhydride 
• 278175-53-4 methyl 4-methoxy-2-(1-pentynyl)benzoate 
• 278175-58-9 4-methoxy-2-(1-pentynyl)benzoic acid 
• 278175-51-2 methyl 4-methoxy-2-(perfluoro-1-butanesulfonyloxy)benzoate 
• 5446-02-6 4-methoxymethylsalicylate 

Relevant academic research and scientific papers

Stereoselective synthesis of (Z)-3-ylidenephthalides via AlCl3-mediated cyclization with 2-acylbenzoic acids

An efficient method for the synthesis of (Z)-3-ylidenephthalides is reported in moderate to high yield with AlCl3 as catalyst. Different substrates of the 2-acylbenzoic acids are well performed in the Z/E selectivity. This method is highlighted

Regioselective synthesis of natural and unnatural (Z)-3-(1- alkylidene)phthalides and 3-substituted isocoumarins starting from methyl 2- hydroxybenzoates

(Z)-3-(1-Alkylidene)phthalides and 3-substituted isocoumarins, which include compounds bearing a substituent on their benzene ring, have been selectively and efficiently synthesized by a new protocol which involves: (i) the conversion of methyl 2-hydroxybenzoates into the corresponding nonaflates; (ii) Pd-catalyzed alkynylation reactions of these derivatives; (iii) the conversion of the so obtained methyl 2-(1-alkynyl)benzoates into the corresponding carboxylic acids followed by a transition metal-catalyzed heteroannulation reaction. This procedure has been used to prepare either natural products such as senkyunolide B, senkyunolide C, 3-propylisocoumarin and artemidin, or the MEM-ether of senkyunolide E. The regioselectivity of the transition metal-catalyzed cyclization reactions of 2-(1-alkynyl)benzoic acids has proven to be affected either by the catalyst used or the type of 1- alkynyl group present in these carboxylic acids. (C) 2000 Elsevier Science Ltd.

A convenient approach for synthesis of (Z)-3-butylidenephthalide derivatives

The reaction of n-BuLi with phthalic anhydride derivatives leads to (Z)-3-butylidenephthalide derivatives.

Efficient Synthesis of Hydroxyphthalides

Naturally occurring hydroxyphthalides were synthesized via migration of double bond regio- and stereoselectively.Isomerization of E-isomer to Z-isomer easily occurred under acidic or basic conditions.