916525-83-2

Upstream product

• 119-52-8 4,4'-dimethoxybenzoin 
• 4464-76-0 (1R,2S)-1,2-bis(4-methoxyphenyl)-1,2-ethanediol 
• 916525-61-6 1,2-bis(4-methoxyphenyl)-2-[(7,8,8-trimethyloctahydro-4,7-methanobenzo[b]furan-2-yl)oxy]ethanol 
• 916525-78-5 oxophenylacetic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester 

Downstream Products

• 17199-29-0 (S)-Mandelic acid 
• 611-71-2 (R)-Mandelic Acid 

Relevant academic research and scientific papers

Chiral linker. Part 3: Synthesis and evaluation of aryl substituted m-hydrobenzoins as solid supported open chain chiral auxiliaries for the diastereoselective reduction of α-keto esters

Five partly novel aryl substituted m-hydrobenzoins were synthesized and the corresponding desymmetrized hydrobenzoin ethers evaluated as open chain chiral auxiliaries in the L-Selectride mediated stereoselective reduction of phenylglyoxylates, resulting in de values of up to 91%. Two optimized auxiliary structures were immobilized on commercially available Wang-resin and applied as a reusable solid supported chiral auxiliary in the same type of reaction.