916595-36-3

Upstream product

• 1062513-35-2 C₃₆H₅₂N₆O₅Si₂ 
• 958-09-8 2'-deoxy-D-adenosine 
• 14985-44-5 8-bromo-2'-deoxyadenosine 
• 1053261-67-8 8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine 
• 1053718-26-5 8-bromo-3',5'-O-tetrakisisopropyldisiloxanediyl-2'-deoxyadenosine 

Downstream Products

• 1053651-54-9 N₆-benzoyl-8N-(4-methoxyphenyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 

Relevant academic research and scientific papers

Synthesis of DNA strands site-specifically damaged by C8-arylamine purine adducts and effects on various DNA polymerases

C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemistry. These adducts were subsequently converted into the corresponding 5′-O-DMTr-C8-arylamine-3′-O-phosphoramidites and then used for the automated synthesi

Synthesis of C8-modified 2′-deoxyadenosine with carcinogenic arylamines

The synthesis of phosphoramidites of C8-modified 2′-deoxyadenosine with carcinogenic arylamines p-anisidine and 4-aminobiphenyl is described. Two different methods were studied related to the glycon and base protection groups. Copyright Taylor & Francis Group, LLC.

First synthesis of C8-arylamine adducts of 2′-deoxyadenosine and incorporation of the phosphoramidite into an oligonucleotide

The synthesis of C8-adducts of 2′-deoxyadenosine 7a,b with carcinogenic arylamines p-anisidine 4c and 4-aminobiphenyl 4b, their conversion into the phosphoramidites and successful incorporation into oligonucleotides are described. Georg Thieme Verlag Stut