91660-71-8

Upstream product

• 13616-37-0 ethyl (tetrazol-5-yl)acetate 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 364630-80-8 [4-(2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-{2-[1-(4-methoxy-benzyl)-1H-tetrazol-5-yl]-acetylamino}-ethyl)-benzyl]-phosphonic acid di-tert-butyl ester 
• 364630-88-6 [4-(2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-{2-[1-(4-methoxy-benzyl)-1H-tetrazol-5-yl]-acetylamino}-ethyl)-phenyl]-acetic acid tert-butyl ester 
• 364631-05-0 2-(5-(4-methoxybenzyl)tetrazolyl)acetyl chloride 
• 957471-86-2 [1-(4-methoxybenzyl)-1H-tetrazol-5-yl]acetic acid 

Relevant academic research and scientific papers

A reagent, ethyl 2-(2-tert-butyl-2H-tetrazol-5-yl)-3-(dimethylamino)acrylate (DMTE), for facile synthesis of 2,3-(ring fused)-5-(5-tetrazolyl)-4H-pyrimidin-4-one derivatives

A method for synthesizing 2,3-(ring fused)-5-(5-tetrazolyl)-4H-pyrimidin-4-one derivatives from ethyl 2-(2-tert-butyl-2H-tetrazol-5-yl)-3-(dimethylamino)acrylate (DMTE) (4a) and amino-heterocycles is described. The structure of DMTE, which was prepared from ethyl (2-tert-butyl-2H-tetrazol-5-yl)acetate (3a) with dimethylformamide diethylacetal, was determined by X-ray analysis to be Z form. The reaction of 2-amino-5-methyloxazole (6) with DMTE in acetic acid gave the oxazolo[3,2-a]pyrimidine derivative (8), heating of which in concentrated sulfuric acid afforded the desired tetrazole derivative (20). Pyrimido[2,1-b]benzothiazole (21), pyrazolo[1,5-a]pyrimidine (22 and 23) and [1,2,4]triazolo[1,5-a]pyrimidine (24) derivatives were prepared in a similar manner.