916651-17-7Relevant academic research and scientific papers
A unified strategy for the regiospecific assembly of homoallyl-substituted butenolides and γ-hydroxybutenolides: First synthesis of luffariellolide
Boukouvalas, John,Robichaud, Jo?l,Maltais, Fran?ois
, p. 2480 - 2482 (2008/02/11)
The first synthesis of the antiinflammatory marine natural product luffariellolide has been achieved by a convergent pathway involving sp 3-sp3 cross-coupling and silyloxyfuran oxyfunctionalisation as key steps. An illustration of the inherent flexibility of this strategy is provided by a simple synthesis of α,β-acariolide and its γ-hydroxylated derivative from a common silyloxyfuran precursor. Georg Thieme Verlag Stuttgart.
