916673-05-7Relevant academic research and scientific papers
Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond
Liu, Gang,Zhao, Hongyu,Liu, Bo,Xin, Zhili,Liu, Mei,Kosogof, Christi,Szczepankiewicz, Bruce G.,Wang, Sanyi,Clampit, Jill E.,Gum, Rebecca J.,Haasch, Deanna L.,Trevillyan, James M.,Sham, Hing L.
, p. 5723 - 5730 (2007/10/03)
The structure-activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand interaction with the kinase specificity and ribose-binding pockets. The syntheses of analogues and the impact of structural modification on in vitro potency and cellular activity are described.
