916675-85-9

Upstream product

• 695188-75-1 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-5,5-dichloro-4-methylpentanoic acid tert-butyl ester 
• 695188-74-0 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-4-methyl-5-oxopentanoic acid tert-butyl ester 
• 695188-70-6 (2S,4S)-5,5-dichloroleucine 
• 159415-79-9 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-5-hydroxy-4-methylpentanoic acid tert-butyl ester 
• 501-53-1 benzyl chloroformate 
• 916675-77-9 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-5,5-dichloro-4-methylhexane-1,6-dioic acid 1-tert-butyl ester 
• 916675-71-3 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-4-methylpentane-1,5-dioic acid 1-tert-butyl 5-allyl diester 
• 916675-76-8 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-5,5-dichloro-4-methyl-6-oxohexanoic acid tert-butyl ester 
• 916675-72-4 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-4-methylpentane-1,5-dioic acid 1-tert-butyl ester 
• 916675-74-6 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-6-hydroxy-4-methylhexanoic acid tert-butyl ester 
• 916675-73-5 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-4-methylhex-5-enoic acid tert-butyl ester 
• 916675-75-7 (2S,4S)-2-(di(tert-butoxycarbonyl)amino)-4-methyl-6-oxohexanoic acid tert-butyl ester 
• 916675-70-2 (2S,4S)-2-((tert-butoxycarbonyl)amino)-4-methylpentane-1,5-dioic acid 1-tert-butyl 5-allyl diester 
• 916675-82-6 (2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of the chlorinated marine natural product dysamide B

Two approaches to the synthesis of (2S,4S)-5,5-dichloroleucine are compared, and the parent amino acid was used in the first total synthesis of the polychlorinaled marine natural product, dysamide B. A key step was the lead tetraacetate-mediated decarboxylation of an α,α-dichloro acid in the presence of 1,4-cyclohexadiene to generate the dichloromethyl group.