916677-46-8

Basic information

• Product Name: N-[1-(2-hydroxyethyl)allyl]-4-methylphenylsulfonylamide
• Synonyms: N-[1-(2-hydroxyethyl)allyl]-4-methylphenylsulfonylamide
• CAS NO: 916677-46-8
• Molecular Weight: 255.338
• Mol File: 916677-46-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[1-(2-hydroxyethyl)allyl]-4-methylphenylsulfonylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(2-hydroxyethyl)allyl]-4-methylphenylsulfonylamide(916677-46-8)
• EPA Substance Registry System: N-[1-(2-hydroxyethyl)allyl]-4-methylphenylsulfonylamide(916677-46-8)

Safety Data

• Hazardous Substances Data: 916677-46-8(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 175431-85-3 3-amino-4-penten-1-ol 
• 916677-44-6 3-(4-methylphenylsulfonyl)-4-vinyl-[1,3]oxazinan-6-one 

Downstream Products

• 74046-07-4 (+)-Vigabatrin 
• 916677-49-1 C₁₃H₁₇NO₄S 

Relevant articles and documents

Modular Construction of Protected 1,2/1,3-Diols, -Amino Alcohols, and -Diamines via Catalytic Asymmetric Dehydrative Allylation: An Application to Synthesis of Sphingosine

A new enantioselective catalysis has been developed for the one-step construction of methylene-bridged chiral modules of 1,2- and 1,3-OH and/or NH function(s) from δ- or λ-OH/NHBoc-substituted allylic alcohols and H2C=O / H2C=NBoc . A protonic nucleophile, either in situ-generated CH2OH or CH2NHBoc, is intramolecularly allylated to furnish eight possible 1,2- or 1,3-O,O, -O,N, -N,O, and -N,N chiral modules equipped with an ethenyl group in high yields and enantioselectivities. The utility of this method has been demonstrated in the five-step synthesis of sphingosine.

Synthesis of vigabatrin

A concise synthesis of vigabatrin has been achieved from trans-(2S,4R)-4-hydroxyproline via the key regioselective Baeyer-Villiger lactonization reaction.