916762-79-3Relevant academic research and scientific papers
Synthesis and antibacterial activity of 4″-O-heteroarylcarbamoyl derivatives of macrolide
Xu, Peng,Liu, Lu,Jin, Zhi-ping,Wang, Guang-qiang,Liu, Jian,Li, Yun,Lei, Ping-sheng
, p. 5507 - 5511 (2008)
A series of novel 4″-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4″-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria.
