916766-83-1

Basic information

• Product Name: 3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole
• Synonyms: 3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole;4-(1-Methyl-1H-pyrazol-3-yl)benzyl bromide;4-(1-Methyl-1H-pyrazol-3-yl)benzyl bromide 97%;4-(1-Methyl-1H-pyrazol-3-yl)benzyl chloride 97%;4-(1-Methyl-1H-pyrazol-3-yl)benzyl chloride;3-[4-(Chloromethyl)phenyl]-1-methyl-1H-pyrazole 97%;3-[4-(Chloromethyl)phenyl]-1-methyl-1H-pyrazole97%;3-(4-(Chloromethyl)
• CAS NO: 916766-83-1
• Molecular Formula: C₁₁H₁₁ClN₂
• Molecular Weight: 206.68
• EINECS: 200-258-5
• Mol File: 916766-83-1.mol

Chemical Properties

• Melting Point: 78 °C
• Boiling Point: 343.3 °C at 760 mmHg
• Flash Point: 161.4 °C
• Appearance: /
• Density: 1.17 g/cm³
• Vapor Pressure: 0.000141mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.53±0.10(Predicted)
• Sensitive: Lachrymatory
• CAS DataBase Reference: 3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole(916766-83-1)
• EPA Substance Registry System: 3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole(916766-83-1)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 916766-83-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
3-[4-(chloromethyl)phenyl]-1-methyl-1H-pyrazole is used as a chemical intermediate for the development of new pharmaceuticals, leveraging its potential biological activities and structural characteristics to create novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic chemistry, 3-[4-(chloromethyl)phenyl]-1-methyl-1H-pyrazole is used as a building block for synthesizing a variety of organic compounds, contributing to the advancement of chemical research and the creation of new materials.
Used in Chemical Research:
3-[4-(chloromethyl)phenyl]-1-methyl-1H-pyrazole is employed as a research tool in chemical laboratories, where it aids in understanding the properties and reactions of pyrazole derivatives and related compounds, furthering scientific knowledge in the field.
Used in Chemical Education:
3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole is also utilized in educational settings, where it serves as a teaching aid to illustrate the principles of organic chemistry, including the synthesis and properties of pyrazole derivatives.
Used in Chemical Safety Training:
Due to its potential hazards, 3-[4-(chloromethyl)phenyl]-1-methyl-1H-pyrazole is used in safety training programs to educate researchers and laboratory workers on the proper handling and disposal of potentially harmful chemicals, emphasizing the importance of safety precautions in chemical research and production.

InChI:InChI=1/C11H11ClN2/c1-14-7-6-11(13-14)10-4-2-9(8-12)3-5-10/h2-7H,8H2,1H3

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 179055-20-0 (4-(1-methyl-1H-pyrazol-3-yl)phenyl)methanol 

Downstream Products

• 1259765-95-1 Triethyl 2-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)ethane-1,1,1-tricarboxylate 

Relevant articles and documents

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Targeting allosteric sites at M1 muscarinic acetylcholine receptors is a promising strategy for the treatment of Alzheimer's disease. Positive allosteric modulators not only may potentiate binding and/or signaling of the endogenous agonist acetylcholine (ACh) but also may possess direct agonist activity (thus referred to as PAM-agonists). Recent studies suggest that PAM-agonists with robust intrinsic efficacy are more likely to produce adverse effects in vivo. Herein we present the synthesis and pharmacological evaluation of a series of pyrrole-3-carboxamides with a diverse range of allosteric profiles. We proposed structural modifications at top, core, or pendant moieties of a prototypical molecule. Although generally there was a correlation between the degree of agonist activity and the modulatory potency of the PAMs, some derivatives displayed weak intrinsic efficacy yet maintained strong allosteric modulation. We also identified molecules with the ability to potentiate mainly the affinity or both affinity and efficacy of ACh.

ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE

The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. (I) wherein each symbol is as described in the specification, or a salt thereof.