916793-23-2Relevant academic research and scientific papers
Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) Reductase in Toxoplasma gondii
Stec, Jozef,Fomovska, Alina,Afanador, Gustavo A.,Muench, Stephen P.,Zhou, Ying,Lai, Bo-Shiun,ElBissati, Kamal,Hickman, Mark R.,Lee, Patty J.,Leed, Susan E.,Auschwitz, Jennifer M.,Sommervile, Caroline,Woods, Stuart,Roberts, Craig W.,Rice, David,Prigge, Sean T.,Mcleod, Rima,Kozikowski, Alan P.
, p. 1138 - 1160 (2013/07/26)
Through our focused effort to discover new and effective agents against toxoplasmosis, a structure-based drug design approach was used to develop a series of potent inhibitors of the enoyl-acyl carrier protein (ACP) reductase (ENR) enzyme in Toxoplasma go
Design of mechanism-based inhibitors of transthyretin amyloidosis: Studies with biphenyl ethers and new structural templates
Gupta, Sarika,Chhibber, Manmohan,Sinha, Sharmistha,Surolia, Avadhesha
, p. 5589 - 5599 (2008/03/17)
Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. In this study, we explore the potential of biphenyl ethers (BPE), which are shown to interact with a high affinity to its T4 binding site t
Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli
Chhibber, Manmohan,Kumar, Gyanendra,Parasuraman, Prasanna,Ramya,Surolia, Namita,Surolia, Avadhesha
, p. 8086 - 8098 (2007/10/03)
We designed some novel diphenyl ethers and determined their binding energies for Enoyl-Acyl Carrier Protein Reductase (ENR) of Plasmodium falciparum using Autodock. Out of these, we synthesized the promising compounds and tested them for their inhibitory
