91680-07-8

Upstream product

• 75353-75-2 anhydride de l'acide methyl-2 quinoleinecarboxylique-3,4 
• 100-46-9 benzylamine 
• 882-36-0 N-benzyl-3-oxobutanamide 
• 91-56-5 indole-2,3-dione 
• 91680-15-8 N-[2-(1-Benzyl-2,5-dioxo-pyrrolidin-3-yl)-phenyl]-acetimidic acid methyl ester 
• 91680-16-9 N-[2-(1-Benzyl-2,5-dioxo-pyrrolidin-3-yl)-phenyl]-thioacetimidic acid ethyl ester 

Relevant academic research and scientific papers

Microwave-assisted solvent-free synthesis of a quinoline-3,4-dicarboximide library on inorganic solid supports

Inorganic solid supports are useful media for the rapid and efficient synthesis of a library of quinoline-3,4-dicarboximides. In particular, wet clay K10 was shown to be the best medium for the condensation reaction between 2-methylquinoline-3,4-dicarboxylic anhydride and several primary amines. Microwave irradiation is essential for a rapid and complete conversion.

Pyrrolo[3,4-c]quinoline-1,3-dione derivatives and synthesis method thereof

The present invention relates to a synthesis method of a pyrrolo[3,4-c]quinoline-1,3-dione derivative, wherein different kinds of pyrrolo[3,4-c]quinoline-1,3-dione derivatives representing various biological activities can be manufactured with a high yield through one step reaction using a low-priced nonmetallic catalyst under a mild condition.COPYRIGHT KIPO 2015

Microwave-assisted synthesis of diverse pyrrolo[3,4- c ]quinoline-1,3- diones and their antibacterial activities

With the aim of developing a general and practical method for library production, a novel and efficient two-phase microwave-assisted cascade reaction between isatins and β-ketoamides in [Bmim]BF4/toluene was developed for the synthesis of pyrrolo[3,4-c]quinoline-1,3-diones. The features of this methodology are, the use of microwave-assisted rapid synthesis, mild reaction conditions, high yields, operational simplicity, facile product separation, and recyclability. Furthermore, the antibacterial activities of the pyrrolo[3,4-c]quinoline-1,3-dione derivatives produced were evaluated against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). These derivatives showed antibacterial activities against Gram-positive strains that were at least equivalent to that against Gram-negative strains. Compound 7{3,5} displayed the most potent antibacterial activity against P. aeruginosa (MIC = 0.5 μg/mL) and greater activity than standard ampicillin (MIC = 1 μg/mL). Compound 7{4,7} exhibited the best inhibitory activity against E. coli and E. aerogenes (MIC = 1 and 0.5 μg/mL), compared with the standard ampicillin (both MICs = 1 μg/mL). The synthesized pyrrolo[3,4-c]quinoline-1,3-diones are expected to be widely used as lead compounds for the development of new antibacterial agents.

Efficient one-step synthesis of pyrrolo[3,4-c]quinoline-1,3-dione derivatives by organocatalytic cascade reactions of isatins and β-ketoamides

We describe an efficient one-step synthesis of pyrrolo[3,4-c]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β-ketoamides. It is the first direct conversion of isatins to pyrrolo[3,4-c]quinolinedione derivatives via C-N bond cleavage and isatin ring expansion. Furthermore, this reaction provides a one-step synthetic route for the production of biologically interesting complex molecules that are generally prepared using multi-step reactions.

STEREO- AND ENANTIOSELECTIVE SYNTHESES OF 2,3-DIHYDROINDOLE DERIVATIVES

2,3-Dihydroindoles (2,3-Indolines) can be obtained in a highly stereoselective fashion through 1,5-electrocyclization of ortho-substituted aminobenzenes.The scope and mechanism of this novel process are discussed and also some applications.In presence of