91690-94-7Relevant academic research and scientific papers
Efficient synthesis of γ-oxo- and γ-hydroxy-α-amino acids
Merla, Beatrix,Grumbach, Hans-Joachim,Risch, Nikolaus
, p. 1609 - 1614 (1998)
The diastereoselective synthesis of anti-γ-oxo-α-aminocarboxylates by aminoalkylation of ketones with in situ generated ternary iminium salts from inexpensive starting materials is described. These compounds are easily transformed diastereoselectively into syn,anti- or anti,anti-γ-hydroxy-α- amino-carboxylates by the use of different reducing agents. The configuration of the products has been determined by NMR. The aminoalkylation of enamines and imines is also reported.
