916923-19-8 Usage
Description
1-(4-Methylphenyl)cyclopropanecarbonyl chloride is a chemical compound characterized by the molecular formula C11H11ClO. It is a halogenated carbonyl compound featuring a cyclopropane ring and a benzenoid group, which makes it a valuable building block for the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
1-(4-Methylphenyl)cyclopropanecarbonyl chloride is used as a versatile reagent for the introduction of the cyclopropane-1-carbonyl functional group into complex molecules. Its reactivity as an acyl chloride makes it a valuable intermediate in the production of various bioactive molecules, including new drug candidates.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Methylphenyl)cyclopropanecarbonyl chloride is utilized as a starting material for the synthesis of agricultural products. Its unique structure and reactivity contribute to the development of novel compounds with potential applications in this field.
Used in Synthesis of Fine Chemicals and Materials:
1-(4-Methylphenyl)cyclopropanecarbonyl chloride is also employed in the synthesis of fine chemicals and materials. Its cyclopropane ring and benzenoid group provide a foundation for creating complex molecular structures with specific properties and functions.
Overall, 1-(4-Methylphenyl)cyclopropanecarbonyl chloride is a multifaceted compound with applications across various industries, including pharmaceuticals, agrochemicals, and the synthesis of fine chemicals and materials. Its unique structure and reactivity make it a promising building block for the development of new bioactive molecules and products.
Check Digit Verification of cas no
The CAS Registry Mumber 916923-19-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,6,9,2 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 916923-19:
(8*9)+(7*1)+(6*6)+(5*9)+(4*2)+(3*3)+(2*1)+(1*9)=188
188 % 10 = 8
So 916923-19-8 is a valid CAS Registry Number.
916923-19-8Relevant articles and documents
Systematic investigation of halogen bonding in protein-ligand interactions
Hardegger, Leo A.,Kuhn, Bernd,Spinnler, Beat,Anselm, Lilli,Ecabert, Robert,Stihle, Martine,Gsell, Bernard,Thoma, Ralf,Diez, Joachim,Benz, Joerg,Plancher, Jean-Marc,Hartmann, Guido,Banner, David W.,Haap, Wolfgang,Diederich, Francois
supporting information; experimental part, p. 314 - 318 (2011/02/28)
Halogen bonding triggers activity: Increasing binding affinity was observed for a series of covalent human Cathepsin L inhibitors by exchanging an aryl ring H atom with Cl, Br, and I, which undergo halogen bonding with the C=O group of Gly61 in the S3 pocket of the enzyme. Fluorine, in contrast, strongly avoids halogen bonding (see scheme). The strong distance and angle dependence of halogen bonding was confirmed for biological systems. Copyright
SULFONAMIDO-MACROCYCLES AS TIE2 INHIBITORS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
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Page/Page column 46; 50-51, (2008/06/13)
The invention relates to sulfonamido-macrocycles according to the general formula (I): in which R1, R2, R4, R5, R6, A, B, C, L, X, Y, Z, n, and m are as defined in the claims, and salts, N-oxides, or
NON-PEPTIDE GnRH AGENTS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION
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Page/Page column 57, (2010/02/11)
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
