916974-60-2Relevant academic research and scientific papers
Structure-activity relationships in platelet-activating factor. Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity
Serradji, Nawal,Bensaid, Okkacha,Martin, Marc,Sallem, Wafa,Dereuddre-Bosquet, Nathalie,Benmehdi, Houcine,Redeuilh, Catherine,Lamouri, Aazdine,Dive, Georges,Clayette, Pascal,Heymans, Francoise
, p. 8109 - 8125 (2007/10/03)
HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series.
