916979-09-4

Basic information

• Product Name: 2-Amino-4-methylpyridine-d6
• Synonyms: 2-Amino-4-methylpyridine-d6;2-AMino-4-picoline-d6;4-Methyl-2-pyridinaMine-d6;AMinopicoline-d6;Ascensil-d6;NSC 1490-d6;NSC 176165-d6;NSC 6972-d6
• CAS NO: 916979-09-4
• Molecular Formula: C6H2D6N2
• Molecular Weight: 114.178090668
• Product Categories: Amines;Aromatics;Heterocycles;Isotope Labelled Compounds
• Mol File: 916979-09-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 86-87°C
• Boiling Point: 227.375 °C at 760 mmHg
• Flash Point: 114.023 °C
• Appearance: /
• Density: 1.128 g/cm³
• Vapor Pressure: 0.078mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate, Methanol,
• CAS DataBase Reference: 2-Amino-4-methylpyridine-d6(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-methylpyridine-d6(916979-09-4)
• EPA Substance Registry System: 2-Amino-4-methylpyridine-d6(916979-09-4)

Safety Data

• Hazardous Substances Data: 916979-09-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

InChI:InChI=1/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)/i1D3,2D,3D,4D

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 

Relevant articles and documents

Synthesis process of rifaximin-D6

The invention provides a synthesis process of rifaximine-D6, which comprises the following steps: 1) by using compounds I2-amino-4-methylpyridine and D2O as raw materials, reacting in the presence of5wt% palladium on carbon and under the protection of nitrogen to obtain a deuterated intermediate, i.e., a compound II 4-methyl-2-aminopyridine-D6; step 2), dissolving rifamycin S and the deuterated intermediate compound II 4-methyl-2-aminopyridine-D6 prepared in the step 1) into dichloromethane; under the protection of nitrogen, stirring at room temperature, dropwise adding a dichloromethane solution dissolved with elemental iodine, reacting at room temperature overnight for 18 hours, dropwise adding an L-ascorbic acid aqueous solution, stirring, and after the reaction is completed, washing and purifying to obtain the product rifaximin-D6. The synthesis method has the following technical effects that the synthesis method of the intermediate II of rifaximin-D6 is simple and convenient, andraw materials are easy to obtain; the steps for synthesizing rifaximin-D6 are simple and short, and the operation is easy.

General method of obtaining deuterium-labeled heterocyclic compounds using neutral D2O with heterogeneous Pd/C

A protocol of a versatile H-D exchange reaction of heterocyclic compounds catalyzed by heterogeneous Pd/C in D2O is described. The reaction of various nitrogen-containing heterocycles with 10% Pd/C (10 wt % of the substrate) under hydrogen atmosphere in D2O as a deuterium source at 110-180 °C for 24 h afforded the corresponding deuterated compounds with satisfactory efficiency of deuteration in moderate to excellent isolated yields. Furthermore, the Pd/C-H2-D2O system can be extended to the direct deuteration of biologically active compounds such as sulfamethazine, which is used as a synthetic antibacterial drug for fat stocks and would be applied as a general method for the preparation of the standard materials for the analysis of residual chemicals in foods and so on.