916981-95-8

Basic information

• Product Name: 3-(1-(benzylimino)ethyl)-4-hydroxy-2H-chromen-2-one
• Synonyms: 3-(1-(benzylimino)ethyl)-4-hydroxy-2H-chromen-2-one
• CAS NO: 916981-95-8
• Molecular Weight: 293.322
• Mol File: 916981-95-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(1-(benzylimino)ethyl)-4-hydroxy-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-(benzylimino)ethyl)-4-hydroxy-2H-chromen-2-one(916981-95-8)
• EPA Substance Registry System: 3-(1-(benzylimino)ethyl)-4-hydroxy-2H-chromen-2-one(916981-95-8)

Safety Data

• Hazardous Substances Data: 916981-95-8(Hazardous Substances Data)

Upstream product

• 2555-37-5 3-acetyl-4-hydroxychromen-2-one 
• 100-46-9 benzylamine 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 

Downstream Products

• 1220118-22-8 3-(1-(benzylamino)ethyl)-4-hydroxy-2H-chromen-2-one 

Relevant articles and documents

Synthesis and Evaluation of 4-Hydroxycoumarin Imines as Inhibitors of Class II Myosins

Inhibitors of muscle myosin ATPases are needed to treat conditions that could be improved by promoting muscle relaxation. The lead compound for this study ((3-(N-butylethanimidoyl)ethyl)-4-hydroxy-2H-chromen-2-one; BHC) was previously discovered to inhibit skeletal myosin II. BHC and 34 analogues were synthesized to explore structure-activity relationships. The properties of analogues, including solubility, stability, and toxicity, suggest that the BHC scaffold may be useful for developing therapeutics. Inhibition of actin-activated ATPase activity of fast skeletal and cardiac muscle myosin II, inhibition of skeletal muscle contractility ex vivo, and slowing of in vitro actin-sliding velocity were measured. Several analogues with aromatic side arms showed improved potency (half-maximal inhibitory concentration (IC50) 1 μM) and selectivity (≥12-fold) for skeletal myosin versus cardiac myosin compared to BHC. Several analogues blocked neurotransmission, suggesting that they are selective for nonmuscle myosin II over skeletal myosin. Competition and molecular docking studies suggest that BHC and blebbistatin bind to the same site on myosin.

An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins

Series of imino and amino derivatives of 4-hydroxy coumarins were synthesized via conventional and microwave promoted procedure and evaluated for antioxidant potential through different in vitro models such as (DPPH) free radical scavenging activity, lino