917080-09-2Relevant academic research and scientific papers
An advantageous synthesis of new indazolone and pyrazolone derivatives
Correa, Arkaitz,Tellitu, Imanol,Domínguez, Esther,SanMartin, Raul
, p. 11100 - 11105 (2006)
The synthesis of new indazolone and pyrazolone derivatives starting from methyl anthranilate type substrates is presented. This general approach constitutes a novel and advantageous alternative for the synthesis of the target heterocycles, which implies the use of the environmentally friendly oxidizer PIFA. The synthetic design includes the oxidation of N-arylamides by the hypervalent iodine reagent to the corresponding N-acylnitrenium ions, which can be intramolecularly trapped by an amine moiety to furnish the title compounds by formation of a new N-N single bond.
